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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
46.97
Human Site:
S358
Identified Species:
73.81
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
S358
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Chimpanzee
Pan troglodytes
XP_524527
588
65774
S358
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
S358
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Dog
Lupus familis
XP_537131
637
71340
S408
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
S357
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Rat
Rattus norvegicus
Q4V8A3
586
65492
S357
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
S317
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
Chicken
Gallus gallus
Q5ZIU3
526
59419
I308
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
Frog
Xenopus laevis
NP_001088793
567
63329
S338
I
K
V
I
D
F
G
S
S
C
F
D
H
Q
R
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
S349
I
K
V
I
D
F
G
S
S
C
F
D
H
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S425
I
K
V
I
D
F
G
S
S
C
F
E
N
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
R600
V
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
S342
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
D258
S
E
Y
I
K
I
P
D
Y
K
F
L
S
R
P
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
S519
L
K
I
I
D
F
G
S
S
C
E
E
A
R
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
73.3
6.6
73.3
73.3
N.A.
80
N.A.
13.3
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
26.6
93.3
93.3
N.A.
86.6
N.A.
26.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
80
0
0
0
0
0
% C
% Asp:
0
0
0
0
80
0
0
7
0
0
0
14
0
0
7
% D
% Glu:
0
7
0
0
0
0
0
0
0
0
7
67
0
0
0
% E
% Phe:
0
0
0
0
0
80
0
0
0
0
67
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
87
0
0
7
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
27
0
0
% H
% Ile:
34
0
7
87
0
7
0
7
0
0
7
0
0
7
0
% I
% Lys:
0
80
0
7
7
0
0
0
0
7
0
7
0
0
40
% K
% Leu:
7
7
7
0
0
0
0
0
0
0
0
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% P
% Gln:
0
7
0
0
7
7
0
0
7
0
0
0
0
74
0
% Q
% Arg:
0
0
7
0
0
0
0
7
0
0
7
0
0
20
34
% R
% Ser:
7
0
0
0
0
0
0
80
87
7
0
0
7
0
0
% S
% Thr:
40
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% T
% Val:
7
0
74
7
0
0
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
7
0
7
0
7
0
14
0
47
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _